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2 edition of Arterial repair after balloon angioplasty and stenting found in the catalog.

Arterial repair after balloon angioplasty and stenting

Asim N. Cheema

Arterial repair after balloon angioplasty and stenting

Role of extracellular matrix and adventitial microvessels in the development of intimal hyperplasia and restenosis

by Asim N. Cheema

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Published .
Written in English


About the Edition

The development of restenosis after percutaneous coronary intervention (PCI) is a major limitation of such procedures and is associated with significant cost and morbidity. Although, the role of smooth muscle cells and vascular intima in arterial repair after PCI has been well investigated, limited information is available regarding the function of extracellular matrix (ECM) and vascular adventitia in this repair response. The research presented in this thesis focuses on these two important aspects of arterial repair (i.e. ECM turnover and changes in adventitial microvessels) in an attempt to identify new targets for therapeutic intervention.Although, collagen and elastin accumulation in the vessel wall has been identified as a critical component of the arterial repair response after PCI, therapeutic implications of these changes remain unclear. In view of the antifibrotic effects of cryotherapy application during tissue repair observed in skin and liver, intravascular cryotherapy was applied after balloon angioplasty in rabbit iliac arteries and effects on collagen accumulation and intimal hyperplasia determined at 72 hours and at 10 weeks. Cryotherapy application produced average vessel wall temperature of -26°C (range, -20°C to -45°C). Despite greater lumen areas noted immediately, both collagen content and intimal hyperplasia was increased two-fold in cryotherapy treated arteries compared to balloon only injured arteries. In addition, marked cell loss and morphologic changes in the form of cartilage and bone formation were noted in cryotherapy treated arteries suggesting that contrary to earlier observations in skin and liver tissue, intravascular cryotherapy after angioplasty increased intimal hyperplasia and induced fibrosis and chondro-metaplasia with no beneficial effects on restenosis. Inhibition of collagen accumulation in the arterial wall after PCI may also be achieved by inhibition of platelet derived growth factor (PDGF) and transforming growth factor beta (TGF beta), two profibrotic growth factors with increased expression after arterial injury. Decorin is a small leucine rich proteoglycan with potent in vitro activity against PDGF and TGF beta and demonstrated antifibrotic properties in animal models. Adenoviral mediated decorin overexpression was achieved in a rabbit carotid angioplasty model to investigate the role of decorin in the prevention of restenosis. Decorin overexpression after angioplasty inhibited both collagen content and intimal area at ten weeks compared to placebo (beta-galactosidase transfected) or injured non-transfected controls. These findings suggest a potential therapeutic role of decorin in the prevention of intimal hyperplasia and restenosis after PCI. (Abstract shortened by UMI.)

Edition Notes

StatementAsim N. Cheema.
The Physical Object
Pagination212 leaves.
Number of Pages212
ID Numbers
Open LibraryOL19887309M
ISBN 100612944492

Objectives: The aim of this study was to evaluate the Tack Endovascular System (Intact Vascular, Wayne, Pennsylvania) for treating dissections following angioplasty in the superficial femoral artery and/or proximal popliteal artery. Background: Dissection after angioplasty of femoropopliteal arteries with either a plain balloon or a drug-coated balloon (DCB) can negatively affect both short. Current status of stents for arterial occlusive disease and endovascular aortic aneurysm repair. Current Surgery, Vol. 62, No. 2. Restenosis after balloon angioplasty and/or stent insertion - origin and prevention. A review of the literature External iliac and common iliac artery angioplasty and stenting in men and women. Journal of.

  Angioplasty is a procedure to open narrowed or blocked blood vessels that supply blood to your legs. Fatty deposits can build up inside the arteries and block blood flow. A stent is a small, metal mesh tube that keeps the artery open. Angioplasty and stent placement are two ways to open blocked peripheral arteries. Angioplasty and Stenting In this procedure, sometimes performed at the time of the angiogram, the vascular surgeon inflates a small balloon inside a narrowed mesenteric artery. After widening the artery with angioplasty,the surgeon may insert a stent, a tiny metallic mesh tube that supports the artery's walls and keeps the blood vessels open.

‘Coronary artery restenosis after balloon angioplasty or stent implantation remains a major limitation to the long-term success of these procedures.’ ‘Cardiovascular surgeons may use ‘cool’ lasers as an alternative to heart bypass surgery and balloon angioplasty.’. Quantitative analysis of elastic recoil after balloon angioplasty and after intracoronary implantation of balloon-expandable Palmaz-Schatz stents Journal of the American College of Cardiology, Vol. 21, No. 1.


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Arterial repair after balloon angioplasty and stenting by Asim N. Cheema Download PDF EPUB FB2

Tyagi S, et al reported that after subclavian angioplasty restenosis was more commonly in TA than atherosclerotic lesions (% Arterial repair after balloon angioplasty and stenting book 10%) on an average 43 months follow-up. 3 Plain balloon angioplasty (POBA) alone demonstrated a better long term patency comparing with bare stent placement in a study.

4 However, for renal artery stenosis caused. About 35% to 40% of patients who have balloon angioplasty are at risk of more blockages in the treated area. This is called restenosis.

Restenosis usually happens within 6 months after balloon angioplasty. Arteries that have stents can re-close, as well. Restenosis occurs in about 20% of patients with stents.

The last 10 years have witnessed tremendous growth in percutaneous interventions for symptomatic coronary artery disease, with more than one million procedures performed worldwide in In most centers, stents are used in >80% of interventional procedures, as they provide both a more reliable immediate result and improved restenosis rates compared with balloon angioplasty Cited by:   A prospective randomized multicenter comparison of balloon angioplasty and infrapopliteal stenting with the sirolimus-eluting stent in patients with ischemic peripheral arterial disease: 1-year results from the ACHILLES trial.

J Am Coll by: 1. Balloon angioplasty is also a minimally invasive procedure performed using a local anesthetic. During balloon angioplasty, the doctor inflates a surgical balloon and pushes it through the catheter and into the blood vessel. Afterward, he or she may place a stent in the vessel.

This enables it to heal after the procedure and improves blood flow. Abdominal Aortic aneurysm/ Ruptured (AAA) (open and endovascular), Thoracoabdominal aneurysm/repair, Carotid artery (CAD) and subclavian artery stenosis-stenting/bypass, Iliac artery reconstruction/aneurysm repair/stent graft repair/balloon angioplasty and stenting; Renal artery angioplasty and stenting/reconstruction/aneurysm repair/bypass; Splenic artery aneurysm repair.

After a balloon angioplasty or stenting procedure, most people are able to return to work and their normal routines after about a week. People who do very physical work will need to wait longer.

Check with your doctor before doing any strenuous physical activity. As with all. Core tip: To evaluate the short and intermediate term outcome of percutaneous transluminal renal artery angioplasty (PTRA) and stenting particularly on blood pressure (BP) control and renal function and to evaluate predictors of poor BP response after successful PTRA and stenting.

The PTRA and stenting can be considered as an effective therapeutic intervention for improving BP. We evaluated short- and long-term vessel wall injury after experimental implantation of two stent designs as well as balloon angioplasty and their relationship to neointimal hyperplasia.

Methods and Results. Wiktor stents and Palmaz-Schatz stents were implanted in normal coronary arteries of pigs (balloon/artery ratio: 09–11). Treatment with coronary stenting with SCAD often requires multiple and very long stents, with subsequent high risk of in-stent restenosis. There is early and increasing interest in using cutting balloon (CB) angioplasty to fenestrate the false lumen to allow communication and back-bleed of intramural hematoma into the true lumen.

Recovery from angioplasty and stenting is typically brief. Discharge from the hospital is usually 12 to 24 hours after the catheter is removed.

Many patients are able to return to work within a few days to a week after a procedure. What to Expect at Home. After an interventional procedure, it is normal to.

An intraluminal coronary artery stent is a small, self-expanding, stainless steel mesh tube that is placed within a coronary artery to keep the vessel open. It may be used during a coronary artery bypass graft surgery to keep the grafted vessel open, after balloon angioplasty to prevent reclosure of the blood vessel, or during other heart.

Stent placement in the artery, which involves a tube, or stent, made out of wire mesh. Stents help to prevent an artery narrowing again after angioplasty.

Stents may. Purpose: To report a percutaneous endovascular technique to deal with stent-graft encroachment and coverage (partial or total) of the origin of the left common carotid artery (CCA) or the left subclavian artery during thoracic endovascular aortic repair.

Technique: Percutaneous retrograde puncture of the left CCA was accomplished with guidewire advancement into the ascending aorta and. What is Coronary Angioplasty and Stenting. Coronary angioplasty is a medical procedure we use to treat coronary heart disease.

It involves inflating a small balloon inside one or more of your coronary arteries to open up an area that has become narrow, improving blood flow to your heart. In most cases, a stent will also be required in the area.

Angioplasty to widen the artery and let more blood flow through and a stent, or small mesh tube, to help keep the artery open Atherectomy to remove plaque Bypass surgery to send blood around the.

with angioplasty. Once in place, the balloon is inflated. This pushes plaque against the wall and opens the stent. The balloon is then deflated and removed, leaving the stent in place. Depending on the size of the plaque, more than one stent may be used per blockage.

After stenting, an angiogram is done to confirm that blood flow has improved. A balloon catheter, placed over a guide wire, puts the stent into your narrowed coronary artery. Once in place, the balloon is inflated, and the stent expands to the size of the artery and holds.

Percutaneous transluminal peripheral angioplasty (PTA), with and without stenting, is an effective, accepted, and safe approach for treating iliac artery occlusive disease. Complications, although infrequent, can occur after PTA and may result in significant disability.

In one review in the. Balloon angioplasty is done in the catheterization laboratory (“cath lab”). The doctor injects a special dye through a small, thin tube called a catheter into your bloodstream.

The dye allows the doctor to view your arteries on an X-ray monitor. Coronary artery stents are small mesh tubes that can help to reduce blockage of a coronary artery. The stent is implanted into an artery and expanded to fit the size, shape and bend of the coronary artery.

The stent is propped open to help prevent any more blockages. Once the stent is in place, the stent will remain in your artery. Over time, the artery wall will heal around the stent as.Summary: Vessel rupture is a rare complication of angioplasty and stent placement of the supraaortic arteries occurring in two (%) of vessels treated at our institution.

Many different approaches to the management of this complication have been proposed. In this report, we present our experience with conservative management in two cases in which vessel rupture occurred and review the.It usually occurs within 6 months after the initial procedure.

1 Compared with balloon angioplasty alone, where the chance of restenosis is 40%, stents reduce the chance of restenosis to 25%. 2,3 Therefore, the majority of patients having angioplasty today are treated with stents.

Restenosis can occur after the use of stents, and physicians.